Henderson is a home rule-class city along the Ohio River and is the county seat of Henderson County in western Kentucky in the United States. The population was 28,757 at the 2010 U.S. census. It is part of the Evansville Metropolitan Area, locally known as the "Tri-State Area". It is considered the southernmost suburb of Evansville, Indiana.
Notable residents have included the ornithologist, naturalist, and painter John James Audubon and blues legend W. C. Handy.
Henderson has its roots in a small, block-wide strip of land high above the Ohio River, the site of the present-day Audubon Mill Park directly south of the city's riverfront boat dock. A village on this site was called "Red Banks" because of the reddish clay soil of the bluffs overlooking the Ohio River. The future city was named after Richard Henderson, an eighteenth-century pioneer and land speculator, by his associates Samuel Hopkins and Thomas Allin. Henderson County also shares this namesake. On March 17, 1775, North Carolina judge Richard Henderson and his Transylvania Company had met with 1,200 Cherokee in a council at Sycamore Shoals (present-day Elizabethton, Tennessee) to purchase over 17,000,000 acres (69,000 km2) of land between the Ohio, Cumberland, and Kentucky rivers in present-day Kentucky and Tennessee to resell it to white settlers.