Holdrege is a city in Phelps County, Nebraska, United States. The population was 5,495 at the 2010 census. It is the county seat of Phelps County. The Nebraska Prairie Museum is located in Holdrege.
Holdrege was established in 1883 when the railroad was extended to that point. It was named for George W. Holdrege, a railroad official. Holdrege was designated county seat in 1884.
According to the United States Census Bureau, the city has a total area of 3.87 square miles (10.02 km2), of which, 3.86 square miles (10.00 km2) is land and 0.01 square miles (0.03 km2) is water.
As of the census of 2010, there were 5,495 people, 2,351 households, and 1,496 families living in the city. The population density was 1,423.6 inhabitants per square mile (549.7/km2). There were 2,589 housing units at an average density of 670.7 per square mile (259.0/km2). The racial makeup of the city was 96.7% White, 0.1% African American, 0.4% Native American, 0.2% Asian, 1.5% from other races, and 1.0% from two or more races.