Independence, originally known as Uncle Sam, is a town in Tangipahoa Parish, Louisiana, United States. The population was 1,665 at the 2010 census. It is part of the Hammond Micropolitan Statistical Area.
The move to establish Independence as a town was led in the early 20th century by State Representative Harry D. Wilson, who subsequently served from 1916 until his death early in 1948 as the Louisiana Commissioner of Agriculture and Forestry. Wilson was a son of Dr. and Mrs. William D. Wilson. In 1856, Dr. Wilson had built a store in Independence, which remained for years the oldest building in the community. Harry Wilson worked in the parish seat of Amite in the general store of the merchant Jacob Stern at a time when Tangipahoa Parish did not yet depend on the strawberry crop.