Irvine (locally ) is a home rule-class city in Estill County, Kentucky, in the United States. It is the seat of its county. Its population was 2,715 at the time of the 2010 census. It is located on the Kentucky River at the junction of Kentucky Route 52 and Kentucky Route 89. Irvine annually hosts the Mountain Mushroom Festival on the last weekend of April. Irvine and nearby Ravenna are known within Estill County as the "Twin Cities".
Irvine is located in the center of Estill County at 37°41′49″N 83°58′1″W (37.696835, -83.966895). The city limits are on the northeast side of the Kentucky River, and the city is bordered by Ravenna to the southeast. According to the United States Census Bureau, Irvine has a total area of 1.49 square miles (3.85 km2), of which 1.41 square miles (3.65 km2) is land and 0.077 square miles (0.20 km2), or 5.13%, is water.
Kentucky Route 89 passes through Irvine as Main Street; Route 52 enters from the east as River Drive, then joins Route 89 to cross the Kentucky River. Route 89 leads north 27 miles (43 km) to Winchester and south 28 miles (45 km) to McKee, while Route 52 leads southeast 26 miles (42 km) to Beattyville and west 19 miles (31 km) to Richmond.