Karlsruhe ( KARLSS-roo) is a city in McHenry County, North Dakota, United States. The population was 82 at the 2010 census. Karlsruhe was founded in 1912.
Old Saints Peter and Paul Cemetery, Wrought-Iron Cross Site, in or near Karlsruhe, is listed on the National Register of Historic Places. Sts. Peter and Paul Catholic Church in Karlsruhe features works by the artist Count Berthold von Imhoff.
Karlsruhe is also included in the Minot micropolitan statistical area.
Karlsruhe was named after the German city of Karlsruhe by Germans from Russia. Karlsruhe was first settled in the late 19th century by German pioneers moving toward northern American prairie lands. These pioneers and their early generations of relatives are buried in the St. Peter and Paul cemetery.