Keokuk is a city in and a county seat of Lee County, Iowa, United States, along with Fort Madison. It is Iowa's southernmost city. The population was 10,780 at the 2010 census. The city is named after the Sauk chief Keokuk, who is thought to be buried in Rand Park. It is in the extreme southeast corner of Iowa, where the Des Moines River meets the Mississippi. It is at the junction of U.S. Routes 61, 136 and 218. Just across the rivers are the towns of Hamilton and Warsaw, Illinois, and Alexandria, Missouri. Keokuk, along with the city of Fort Madison, is a principal city of the Fort Madison-Keokuk micropolitan area, which includes all of Lee County, Iowa, Hancock County, Illinois and Clark County, Missouri.
Situated between the Des Moines and Mississippi rivers, the area that became Keokuk had access to a large trading area and was an ideal location for settlers. In 1820, the US Army prohibited soldiers stationed along the Mississippi River from having wives who were Native American.