Kotzebue ( KOTS-ə-bew) or Qikiqtaġruk (Inupiaq: Qikiqtaġruk [qekeqtɑʁʐuk]) is a city in the Northwest Arctic Borough in the U.S. state of Alaska. It is the borough's seat, by far its largest community and the economic and transportation hub of the subregion of Alaska encompassing the borough. The population of the city was 3,201 as of the 2010 census, up from 3,082 in 2000. The city has an All-America City award
Owing to its location and relative size, Kotzebue served as a trading and gathering center for the various communities in the region. The Noatak, Selawik and Kobuk Rivers drain into the Kotzebue Sound near Kotzebue to form a center for transportation to points inland. In addition to people from interior villages, inhabitants of far-eastern Asia, now the Russian Far East, came to trade at Kotzebue. Furs, seal-oil, hides, rifles, ammunition, and seal skins were some of the items traded. People also gathered for competitions like the current World Eskimo Indian Olympics. With the arrival of the whalers, traders, gold seekers, and missionaries the trading center expanded.
Kotzebue is also known as Qikiqtaġruk, which means "small island" in Iñupiatun, the language spoken by Iñupiat.