Leesburg is a city in Lee County, Georgia, United States. The population was 2,896 at the 2010 census, up from 2,633 at the 2000 census. The city is the county seat of Lee County and is part of the Albany, Georgia Metropolitan Statistical Area.
The area was an important center for the study of malaria in 1924. A graduate student named Lowell T. Coggeshall collected anopheline larvae in a swamp near Leesburg. Later he helped mastermind the U.S. government's Malaria Project.
Leesburg, originally known as "Wooten Station", was founded in 1870 as the Central of Georgia Railway arrived in the area. In 1872, the town was renamed "Wooten", and the seat was transferred from Starksville. In 1874, the town was incorporated and renamed again to its present form of Leesburg.
Leesburg was the site of a malaria research station established by the International Health Board in 1924; 74 African American children were selected for study with splenic enlargement, a sign of malaria.
Leesburg is the site of the Leesburg Stockade incident, in which a group of African-American teenage and pre-teen girls were arrested for protesting racial segregation in Americus, Georgia, and were imprisoned without charges for 45 days in poor conditions in the Lee County Public Works building.
Leesburg is in south-central Lee County. U.S. Route 19 passes through the city, leading north 26 miles (42 km) to Americus and south 11 miles (18 km) to Albany.