Lexington is the county seat of Davidson County, North Carolina, United States. As of the 2010 census, the city had a population of 18,931. It is located in central North Carolina, 20 miles (32 km) south of Winston-Salem. Major highways include I-85, I-85B, U.S. Route 29, U.S. Route 70, U.S. Route 52 (soon to be I-285) and U.S. Route 64. Lexington is part of the Piedmont Triad region of the state.
Lexington, Thomasville, and the rural areas surrounding them are slowly developing as residential bedroom communities for nearby cities such as Winston-Salem, Greensboro, High Point and, to a lesser extent, Charlotte and its northeastern suburbs.
The Lexington area was at least sparsely settled by Europeans in 1775. The settlers named their community in honor of Lexington, Massachusetts, the site of the first skirmish of the American Revolutionary War. Lexington was incorporated as a city in 1828. Silver Hill Mine, located a few miles south of Lexington, opened in 1838, and was the first operating silver mine in the country.
The oldest surviving house in Lexington is The Homestead, built by Dr. William Rainey Holt (1798–1868), a physician born in what is today Alamance County.