Lexington is a city in Dawson County, Nebraska, United States. The population was 10,230 at the 2010 census. It is the county seat of Dawson County. Lexington is located in southern Nebraska, on the Platte River, southeast of North Platte. It sits along the route of U.S. Route 30 and the Union Pacific Railroad. In the 1860s it was the location of a stop along the Pony Express.
Lexington began as a frontier trading post in 1860. The post was later destroyed. Fort Plum Creek was established near its ruins in 1864. Lexington was founded in 1871.