Little River is a census-designated place (CDP) in Horry County, South Carolina, United States. The population was 8,960 at the 2010 census.
Little River is named for the Little River, which flows into the Atlantic Ocean at the border between North and South Carolina. The inlet has long been a breakpoint for tropical cyclone warnings.
Little River is located at 33°52′18″N 78°37′40″W (33.871629, -78.627733).
According to the United States Census Bureau, the CDP has a total area of 10.8 square miles (28.0 km2), of which 10.5 square miles (27.1 km2) is land and 0.4 square mile (0.9 km2) (3.33%) is water. The area is mainly made up of old scrub pine forests, marshes and swamps and is bordered by the Waccamaw River and the Atlantic Intracoastal waterway. Live oaks, Spanish moss and palm trees dot the landscape.
As of the census of 2000, there were 7,027 people, 3,287 households, and 2,225 families residing in the CDP. The population density was 671.9 people per square mile (259.4/km2). There were 4,715 housing units at an average density of 450.8/sq mi (174.0/km2). The racial makeup of the CDP was 91.40% White, 6.80% African American, 0.43% Native American, 0.28% Asian, 0.04% Pacific Islander, 0.34% from other races, and 0.70% from two or more races.