Mission Hill is a town in Yankton County, South Dakota, United States. The population was 177 at the 2010 census.
Mission Hill was laid out in 1894. The town was named for a nearby hill where a church stood. A post office called Mission Hill has been in operation since 1892.
According to the United States Census Bureau, the town has a total area of 0.33 square miles (0.85 km2), all of it land.
Mission Hill has been assigned the ZIP code 57046 and the FIPS place code 42980.
As of the census of 2010, there were 177 people, 69 households, and 51 families residing in the town. The population density was 536.4 inhabitants per square mile (207.1/km2). There were 77 housing units at an average density of 233.3 per square mile (90.1/km2). The racial makeup of the town was 98.3% White, 1.1% Native American, and 0.6% from other races. Hispanic or Latino of any race were 1.1% of the population.