Mitchell is a city in, and the county seat of, Davison County, South Dakota, United States. The population was 15,254 at the 2010 census making it the sixth most populous city in South Dakota.
Mitchell is the principal city of the Mitchell Micropolitan Statistical Area, which includes all of Davison and Hanson counties.
The first settlement at Mitchell was made in 1879. Mitchell was incorporated in 1883. It was named for Milwaukee banker Alexander Mitchell, President of the Chicago, Milwaukee, and St. Paul Railroad (Milwaukee Road).
Mitchell is located at 43°42′50″N 98°1′35″W (43.713896, -98.026282), on the James River.
According to the United States Census Bureau, the city has a total area of 12.14 square miles (31.44 km2), of which 11.14 square miles (28.85 km2) is land and 1.00 square mile (2.59 km2) is water.
Mitchell has been assigned the ZIP code 57301 and the FIPS place code 43100.
Mitchell has a humid continental climate, the Upper Midwest, with cold winters and warm sometimes humid summers. Average daytime summer temperatures range from 86 °F (30 °C) during the day, and 62 °F (16 °C) during the night, and winter daytime temperatures average 26 °F (-3 °C) during the day, and 4 °F ( -15 °C) during the night.