Muscatine is a city in Muscatine County, Iowa, United States. The population was 22,886 at the 2010 census, an increase from 22,697 in 2000. The county seat of Muscatine County, it is located along the Mississippi River. The local business association states that the name Muscatine is not used by any other community.
Muscatine is the principal city of the Muscatine Micropolitan Statistical Area (2010 census population 54,132) as of 2011 the estimate was 54,184, which includes all of Muscatine and Louisa counties, making it the 208th-largest Micropolitan Statistical Area.
Muscatine began as a trading post founded by representatives of Colonel George Davenport in 1833. Muscatine was incorporated as Bloomington in 1839; the name was changed to reduce mail delivery confusion, as there were several Bloomingtons in the Midwest. Before that, Muscatine had also been known as "Newburg" and "Casey's Landing".
The origin of the name Muscatine is debated. It may have been derived from the Mascouten Native American tribe. The Mascoutin lived along the Mississippi in the 1700s. In 1819 Muscatine Island was known as Mascoutin Island.