Oxford is a village in Furnas and Harlan counties in the U.S. state of Nebraska. The population was 779 at the 2010 census.
Oxford was established as a town in 1880, when the railroad was extended to that point.
Oxford is located at 40°15′8″N 99°37′58″W (40.252091, -99.632913). Most of Oxford is in Furnas County, while a small portion lies in Harlan County.
According to the United States Census Bureau, the village has a total area of 0.95 square miles (2.46 km2), all land.
As of the census of 2010, there were 779 people, 349 households, and 213 families living in the village. The population density was 820.0 inhabitants per square mile (316.6/km2). There were 439 housing units at an average density of 462.1 per square mile (178.4/km2). The racial makeup of the village was 96.0% White, 0.1% African American, 1.2% Native American, 0.4% Asian, 1.5% from other races, and 0.8% from two or more races. Hispanic or Latino of any race were 3.2% of the population.
There were 349 households, of which 27.5% had children under the age of 18 living with them, 48.7% were married couples living together, 8.0% had a female householder with no husband present, 4.3% had a male householder with no wife present, and 39.0% were non-families.