Pascagoula pə-ska-goo-lə is a city in Jackson County, Mississippi, United States. It is the principal city of the Pascagoula Metropolitan Statistical Area, as a part of the Gulfport–Biloxi–Pascagoula Combined Statistical Area. The population was 22,392 at the 2010 census, down from 26,200 at the 2000 census. As of 2019 the estimated population was 21,699. It is the county seat of Jackson County.
The city is served by three airports: Mobile Regional Airport, 34 miles (55 km) to the northeast in Alabama; Gulfport-Biloxi International Airport, about 40 miles (64 km) west of Pascagoula; and the Trent Lott International Airport, 9 miles (14 km) to the north in Jackson County.
The current mayor of the city is Steve Demetropoulos.
The name Pascagoula, which means "bread eater", is taken from a group of Native Americans found in villages along the Pascagoula River some distance above its mouth. Hernando de Soto seems to have made the first contact with them in the 1540s, though little is known of that encounter. Pierre Le Moyne d'Iberville, founder of the colony of Louisiana, left a more detailed account from an expedition of this region in 1700. The first detailed account comes from Jean-Baptiste Le Moyne de Bienville, younger brother of Iberville, whom the Pascagoula visited at Fort Maurepas in present-day Ocean Springs, shortly after it was settled and while the older brother was away in France.