Pendleton is a town in Fall Creek Township, Madison County, Indiana, United States. The population was 4,253 at the 2010 census.
Pendleton was platted in 1830, and incorporated as a town in 1854. It was named for town founder Thomas Pendleton.
Frederick Douglass wrote of being attacked by a mob as he promoted the Abolition cause in 1843. His party had erected a platform in nearby woods. A crowd of "rough characters", largely from "Andersonville", tried to silence them, then severely beat them. He defended himself with a stick, but was knocked unconscious. He was nursed back to health over days by the Quaker Neal Harvey and his wife. Douglass never regained full use of his injured hand.
Pendleton was struck by a strong tornado during the evening of May 27, 2019, during a major tornado outbreak. Moderate damage was reported to the town, with search and rescue efforts beginning that night.