Pfafftown (pronounced "Poff-town”, North Carolina is an unincorporated community which has been partially annexed into the cities of Winston-Salem in Forsyth County and Lewisville, also in Forsyth County. As of the 2000 census, the ZCTA of Pfafftown had a population of 2,043. It is a Piedmont Triad community.
In 1784, Peter Pfaff Sr. bought land west of Muddy Creek. A post office came to the community in 1888.
Pfaff's house, the John Jacob Schaub House and Waller House are listed on the National Register of Historic Places.
After Clemmons and Lewisville incorporated, Pfafftown tried in 2001 to do the same but was not successful. Instead, much of the community was annexed by Lewisville or Winston-Salem in 2006.
Pfafftown's Zip Code Tabulation Area (ZCTA) has a population of about 2,043 as of the 2000 census. The population is about 49% male and 51% female. About 86.6% of the population is white, 8% African-American, 3.2% American Indian, 0.6% Asian, 1.5% Hispanic, and 0.8% of another race. 0.9% of people are two or more races.