Plaquemine is a city in and the parish seat of Iberville Parish, Louisiana, United States. The population was 7,119 at the 2010 census. It is part of the Baton Rouge Metropolitan Statistical Area.
Early inhabitants of the area were the Chitimacha people. Pierre Le Moyne d'Iberville claimed all of Louisiana in 1699 for King Louis XIV of France. Plaquemine was settled by 1775 and named for the Native word Plakemine, which means persimmon.
Due to its location at the juncture of the Bayou Plaquemine and the Mississippi River, the village soon began to prosper and grow, beginning a long history of prosperity. By 1838, the town was incorporated, electing Zenon LaBauve, for whom a street in New Orleans' Garden District is named, as its first mayor.
Plaquemine continued to grow in the Antebellum era. Massive plantations were established in nearby regions, including St. Louis, Nottoway, and Belle Grove. The town has been the seat of Iberville Parish government since its incorporation.