Santa Clara is a city in Washington County, Utah, United States and is a part of the St. George Metropolitan Area. The population was 6,003 at the 2010 census, up from 4,630 at the 2000 census. The city is a western suburb of St. George.
According to the United States Census Bureau, the city has a total area of 4.9 square miles (12.7 km2), of which 4.9 square miles (12.6 km2) is land and 0.04 square mile (0.1 km2) (0.41%) is water.
In 1854, Jacob Hamblin was called by Brigham Young to serve a mission to the southern Paiute and settled at Santa Clara in the vicinity of the modern city of St. George, Utah. The town is among the oldest in the area.
The first settlers built Fort Clara or Fort Santa Clara, in the winter of 1855–1856.