Science Hill is a home rule-class city in Pulaski County, Kentucky, in the United States. The population was 693 as of the 2010 U.S. Census.
The community was named by geologist William J. Bobbitt, who visited to gather and analyze the local rocks, and applied to the local post office by William B. Gragg in 1874.
Science Hill is located at 37°10′31″N 84°38′8″W (37.175284, -84.635654). According to the United States Census Bureau, the city has a total area of 0.6 square miles (1.6 km2), all land. The city is concentrated atop a small hill along Kentucky Route 635. Kentucky Route 1247 passes through the city just east of its downtown area, and U.S. Route 27 passes along the city's eastern border. The Big Clifty Creek Valley lies just to the west of Science Hill.
As of the census of 2000, there were 634 people, 249 households, and 184 families residing in the city. The population density was 1,013.0 inhabitants per square mile (388.6/km2). There were 275 housing units at an average density of 439.4 per square mile (168.5/km2). The racial makeup of the city was 99.21% White, 0.16% Native American, and 0.63% from two or more races.