Trenton is a city in Gilchrist County, Florida, United States. The population was 1,999 as of the 2010 census, and in 2018 it was estimated to be 2,125. It is the county seat of Gilchrist County.
Trenton is located near the southern border of Gilchrist County at 29°36′54″N 82°49′4″W (29.615081, -82.817732). U.S. Route 129 is the city's Main Street; it leads north 28 miles (45 km) to Branford and south 11 miles (18 km) to Chiefland. Florida State Road 26 (Wade Street) leads east 13 miles (21 km) to Newberry and 30 miles (48 km) to Gainesville, while to the west it leads 8 miles (13 km) to Fanning Springs. Florida State Road 47 (Trenton Boulevard) intersects US 129 in the northern part of Trenton and leads northeast 42 miles (68 km) to Lake City.
According to the United States Census Bureau, the city of Trenton has a total area of 3.4 square miles (8.8 km2), all land.
Trenton is in a rural area and is the hometown of country music singer Easton Corbin. The Florida Department of Corrections' nearby Lancaster Correctional Institution is 3 miles (5 km) from Trenton.
The first Paleo-Indians reached the central Florida area near the end of the last ice age, as they followed big game south. As the ice melted and sea levels rose, these Native Americans ended up staying and thrived on the peninsula for thousands of years.