Vanderbilt is a borough in Fayette County, Pennsylvania, United States. The population was 476 at the 2010 census, down from 553 at the 2000 census. The town is named for the railroad tycoon Cornelius Vanderbilt. It is served by the Connellsville Area School District.
Vanderbilt is located in northern Fayette County at 40°2′3″N 79°39′50″W (40.034078, -79.663825).
According to the United States Census Bureau, the borough has a total area of 0.18 square miles (0.454 km2), all of it land.
As of the census of 2000, there were 553 people, 222 households, and 150 families residing in the borough. The population density was 2,995.9 people per square mile (1,186.2/km2). There were 234 housing units at an average density of 1,267.7 per square mile (501.9/km2). The racial makeup of the borough was 96.56% White and 3.44% African American.
There were 222 households, out of which 29.3% had children under the age of 18 living with them, 52.3% were married couples living together, 13.1% had a female householder with no husband present, and 32.4% were non-families. 27.5% of all households were made up of individuals, and 12.6% had someone living alone who was 65 years of age or older.