Wessington is a city on the border between Beadle and Hand counties in South Dakota, United States. The population was 170 at the 2010 census.
The community hosts its annual Fun Days celebration each July.
A post office has been in operation in Wessington since 1882. The city took its name from the nearby Wessington Hills.
The early growth of Wessington began because it was a transshipment point for locally produced grains because of the railroad (C. & N.W. Ry. Co.). This allowed local producers lower shipping costs compared to villages further from railroads, encouraging the location of other businesses in the town. Wessington originally was located in Beadle County, and the cohesiveness the community soon led to growth into neighboring Hand County.
In 1918 there was a flourishing natural ice business that provisioned refrigerated freight cars. The cattle industry in the area has increased the market quality of the nation's cattle through improvements in herd management and adaptations to changing consumer demands.