West Seneca is a town in Erie County, New York, United States. The population was 44,711 at the 2010 census. West Seneca is a centrally located interior town of the county, and a suburb of Buffalo. West Seneca, Orchard Park and Hamburg form the inner "Southtowns", a cluster of middle-class suburban towns.
Because the town is on land of the former Buffalo Creek Reservation, it was not open to white settlement until the mid-19th century.
In 1851, the town of Seneca was formed from parts of the towns of Cheektowaga and Hamburg. The town changed the name to "West Seneca" in 1852 to avoid confusion with the town of Seneca in Ontario County, New York. In 1909 the area immediately south of Buffalo split from West Seneca, becoming the city of Lackawanna.
The Eaton Site was listed on the National Register of Historic Places in 1979. The Community of True Inspiration Residence was listed in 2013.
West Seneca offers a community-rich suburban lifestyle. The town and local businesses sponsor a large number of family oriented community events and festivals.