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Weston is a city in Platte County, Missouri within the United States. The population was 1,641 at the 2010 census. It lies within the Kansas City metropolitan area.
Lewis and Clark Expedition stopped at "Bear Medison" island, near the location of today's city hall. Weston was the oldest settlement in the Platte Purchase of 1836 and was therefore also the farthest western settlement (thus, "West Town") in the United States until the admission of Texas as a state in 1845. Another suggested theory of origin is related to a story about a discharged US Army dragoon by the name of Joseph Moore. He bought the land and then had First Sergeant Tom Weston of D Company, First Dragoons, stationed at Fort Leavenworth across the Missouri River, lay out a town plan. It is this individual after whom the town is named.
William "Buffalo Bill" Cody was at one time a resident of Weston, and the town was a major "jumping off" point for the Santa Fe Trail, the Oregon Trail and the California Gold Rush.
In 1881, Weston was the site of the lynching of the biracial Charles Reese after he was accused of the rape and murder of the sixteen-year-old Nancy Stillwell.
Weston was, at one time, the second largest port on the Missouri River, surpassing both Kansas City and St.