Wilson is a city in Mississippi County, Arkansas, United States. The community is located in the Arkansas Delta and is surrounded by fertile cropland historically used to produce cotton. Wilson started as a company town in 1886 by Robert E. Lee Wilson, who would build a cotton empire and run it from the city. The Wilson Company would become so successful that all of the town's buildings were rebuilt in Tudor Revival architectural style following Wilson's son's honeymoon to England in 1925. Wilson did not incorporate until 1959. Lee Wilson and Company remained in the Wilson family until 2010. The community has seen a rapid decline in economic activity and population since the advent of mechanization on the farm, reducing the need for manual labor to produce cotton. The population was 903 at the 2010 census. The town is incorporated and does not have an owner.
Wilson started as a company town for Robert E. Lee Wilson's nearby logging and sawmill operation founded in 1886.