Wyocena is a village in Columbia County, Wisconsin, United States. The population was 768 at the 2010 census. The village is located within the Town of Wyocena. It is part of the Madison Metropolitan Statistical Area.
A tornado struck the village on April 25, 2008 destroying several homes.
Wyocena is located at 43°29′39″N 89°18′33″W (43.494319, -89.309191).
According to the United States Census Bureau, the village has a total area of 1.55 square miles (4.01 km2), of which, 1.42 square miles (3.68 km2) of it is land and 0.13 square miles (0.34 km2) is water.
Wyocena is served by Wis 16 and Wis 22. Wis 16 heads east to Columbus and west to Poynette and Portage. Wis 22 heads north to Pardeeville and Montello and south to US Route 51 at North Leeds. Wis 22 South is the most direct way to get to Madison via US 51 South.
As of the census of 2010, there were 768 people, 271 households, and 170 families living in the village. The population density was 540.8 inhabitants per square mile (208.8/km2).