Brandywine is the name of an unincorporated area in Prince George's County, Maryland, United States, that refers both to a census-designated place (CDP) and a zip code area which is much larger (20613), whose areas overlap. The population of Brandywine at the 2010 U.S. Census was 6,719 for the CDP, and the population of ZIP code 20613 was 11,860 in 2010.
The CDP and town are adjacent to the southern border of Prince George's County, lying east and west of busy Maryland Route 5/U.S. Route 301, which merge at Brandywine. Brandywine CDP is bordered by Accokeek to the west, Clinton and Rosaryville to the north, Croom to the northeast, and Cedarville to the southeast, all in Prince George's County. Waldorf in Charles County borders Brandywine to the south. The Brandywine zip code area encompasses parts of both counties and includes Cedarville and Baden.
Designated as part of the Prince George's County rural tier, it is primarily rural with a suburban and commercial center.
As of the census of 2000, there were 1,410 people, 478 households, and 377 families residing in the CDP. The population density was 320.4 people per square mile (123.7/km2). There were 501 housing units at an average density of 113.8/sq mi (44.0/km2). The racial makeup of the CDP was 56.24% White, 38.23% African American, 1.13% Native American, 1.13% Asian, 0.07% Pacific Islander, 0.57% from other races, and 2.62% from two or more races. Hispanic or Latino of any race were 0.71% of the population.