Cherokee is a city in Cherokee County, Iowa, United States. The population was 5,253 at the 2010 Census, down from 5,369 in 2000. It is the county seat of Cherokee County.
Cherokee was laid out as a town in 1870, and was named for the Indian tribe. Cherokee was incorporated on April 5, 1873.
According to the United States Census Bureau, the city has a total area of 6.45 square miles (16.71 km2), of which 6.43 square miles (16.65 km2) is land and 0.02 square miles (0.05 km2) is water.
At the 2010 census there were 5,253 people in 2,316 households, including 1,339 families, in the city. The population density was 817.0 inhabitants per square mile (315.4/km2). There were 2,569 housing units at an average density of 399.5 per square mile (154.2/km2). The racial makeup of the city was 95.5% White, 1.0% African American, 0.3% Native American, 0.7% Asian, 0.2% Pacific Islander, 1.2% from other races, and 1.1% from two or more races. Hispanic or Latino of any race were 2.9%.
Of the 2,316 households 24.6% had children under the age of 18 living with them, 43.9% were married couples living together, 9.6% had a female householder with no husband present, 4.3% had a male householder with no wife present, and 42.2% were non-families. 37.3% of households were one person and 16.9% were one person aged 65 or older. The average household size was 2.14 and the average family size was 2.77.