Des Peres (English: ) is a city in west St. Louis County, Missouri, United States. The population was 8,373 at the 2010 census.
The first inhabitants of Des Peres were the Cahokia, the Kaskaskia, the Mitchigamea, the Moingona, and the Tamaroa peoples.
The Osage Nation lived in the area around Des Peres. The Osage were members of the Dhegiha Sioux group of tribes. This group also included the Ponca tribe, Quapaw tribe, Kansas tribe, and Omaha tribe.
Des Peres is thought to be the oldest white settlement in Missouri, founded about December 3, 1700 by a group of Kaskaskia Native Americans and French who had left the camp of the confederated Illinois tribes on the Illinois River. The settlement was called Des Peres, French for "The Fathers," and meant to honor the Spanish missionaries who settled there. This settlement was at the mouth of River des Peres and it is thought the first settlers found this region unhealthful, so moved across the Mississippi River to a prairie about 25 miles from the mouth of the Kaskaskia River.
People of European descent began settling in Des Peres in the 1800s. By 1850, there were 75,000 people living in St. Louis.