Endicott is a village in Jefferson County, Nebraska, United States. The population was 132 at the 2010 census.
Endicott was platted in 1880 at the junction of the St. Joseph and Western and Chicago, Burlington and Quincy Railroads. It was named for William Crowninshield Endicott, the United States Secretary of War in the Administration of President Grover Cleveland. The Endicott family were stockholders in the Chicago, Burlington and Quincy Railroad.
Endicott is located at 40°4′54″N 97°5′50″W (40.081618, -97.097265).
According to the United States Census Bureau, the village has a total area of 0.47 square miles (1.22 km2), of which 0.46 square miles (1.19 km2) is land and 0.01 square miles (0.03 km2) is water.
As of the census of 2010, there were 132 people, 61 households, and 41 families residing in the village. The population density was 287.0 inhabitants per square mile (110.8/km2). There were 72 housing units at an average density of 156.5 per square mile (60.4/km2). The racial makeup of the village was 100.0% White. Hispanic or Latino of any race were 0.8% of the population.