Florence is a city in, and the county seat of, Lauderdale County, Alabama, United States, in the state's northwest corner. It is situated along the Tennessee River.
According to the 2010 census, the city's population was 39,319.
Florence is the largest and principal city of the Florence-Muscle Shoals Metropolitan Statistical Area commonly known as "The Shoals" (which includes the cities of Muscle Shoals, Sheffield, and Tuscumbia in Colbert and Lauderdale counties). Florence is considered northwestern Alabama's primary economic hub.
Annual tourism events include the W. C. Handy Music Festival in the summer and the Renaissance Faire in the fall. Landmarks in Florence include the Rosenbaum House, the only Frank Lloyd Wright-designed home located in Alabama.
Florence and Lauderdale County had one hospital, Eliza Coffee Memorial Hospital. ECM was a 358-bed facility owned by RCCH HealthCare Partners in Brentwood, Tennessee. In 2010 RCCH HealthCare Partners announced that they would build a new hospital in Florence.