Tuscumbia is a city in and the county seat of Colbert County, Alabama, United States. As of the 2010 census, the population was 8,423. The city is part of The Shoals metropolitan area.
Tuscumbia was the hometown of Helen Keller (Ivy Green) and much of the city is listed on the National Register of Historic Places as the Tuscumbia Historic District. The city serves as the location for the Alabama Music Hall of Fame.
Tuscumbia had its beginnings when the Michael Dixon family arrived about 1816. They traded with Chief Tucumseh for the Tuscumbia Valley and built their home at the head of the big spring. From these humble dwellings quickly developed a village known as the Big Spring Community. The men of the community requested that the state legislature incorporate them as a city. The town was incorporated in 1820 as Ococoposa and is one of Alabama's oldest towns.