Greenville is a city in, and the county seat of, Washington County, Mississippi, United States. The population was 34,400 at the 2010 census. It is located in the area of historic cotton plantations and culture known as the Mississippi Delta.
This area was occupied by indigenous peoples for thousands of years. When the French explored here, they encountered the historic Natchez people. As part of their colony known as La Louisiane, the French established a settlement at what became Natchez, Mississippi. Other Native American tribes also lived in what is now known as Mississippi.
The current city of Greenville is the third in the State to bear the name. The first, located to the south near Natchez, became defunct soon after the American Revolution, as European-American settlement was then still concentrated in the eastern states.
The second Greenville was founded in 1824 by American William W. Blanton, who filed for land from the United States government.