Metcalfe is a town in Washington County, Mississippi, United States. The population was 1,067 at the 2010 census. The county is located on the western border of the state, with the Mississippi River on the west. It is within the Mississippi Delta.
According to the United States Census Bureau, the town has a total area of 1.0 square mile (2.6 km2), all land.
The climate in this area is characterized by hot, humid summers and generally mild to cool winters. According to the Köppen Climate Classification system, Metcalfe has a humid subtropical climate, abbreviated "Cfa" on climate maps.
At the 2000 census there were 1,109 people, 386 households, and 272 families in the town. The population density was 1,110.5 people per square mile (428.2/km2). There were 417 housing units at an average density of 417.5 per square mile (161.0/km2). The racial makeup of the town was 1.17% White, 97.57% African American, 0.27% Native American, 0.36% from other races, and 0.63% from two or more races.