Guayama (Spanish: [ɡwaˈʝama]), officially the Autonomous Municipality of Guayama (Spanish: Municipio Autónomo de Guayama) is a city and municipality on the Caribbean coast of Puerto Rico. As of the 2010 U.S. Census, the city had a population of 45,362. It is the center of the Guayama metropolitan area, which was home to 84,214 in 2010.
During the early years of the Spanish colonization, the region known today as Guayama was inhabited by Taíno Native People. The indigenous population in this area decreased due to slavery and migration to the Lesser Antilles. The following centuries, the region was under attack from the Taíno rebellion, Caribs and pirates. The town was founded on January 29, 1736 as San Antonio de Padua de Guayama by then Spanish Governor Matías de Abadía, although there is knowledge of it being populated by native people as early as 1567. Guayama took its name from an Indian leader, or cacique who governed the Southeastern region of the Island, the Guamaní cacique and the Guayama cacique. The meaning of the Indian name is "Great Place" (in Spanish Sitio Grande). It was Governor Don Tomás de Abadía who officially declared Guayama a "pueblo" (town) with the name of San Antonio de Padua de Guayama.