Hanapepe or Hanapēpē is a historic, unincorporated community in Kauai County, Hawaii, United States. The name means "crushed bay" in Hawaiian, which may refer to landslides in the area. For statistical purposes, the United States Census Bureau has defined Hanapepe as a census-designated place (CDP). The census definition of the area may not precisely correspond to local understanding of the area with the same name. The population was 2,638 at the 2010 census, up from 2,153 at the 2000 census.
Hanapepe was one of the locations visited by the United States Exploring Expedition under Charles Wilkes; the expedition arrived in Hawaii in late September 1840 and spent some time in the islands.
It is one of the few towns on the island that was not created by the sugarcane plantations. In 1924, an armed labor dispute involving sugar workers occurred, ending in the Hanapepe massacre.
On August 27, 1980, Douglas Kenney, a co-writer of the film National Lampoon's Animal House, fell 30 feet (9.1 m) to his death from the Hanapepe Lookout.
The town was the inspiration for Kokaua Town, the fictional hometown of the main characters in the Disney animated film Lilo & Stitch and its related franchise (the town was not named until Lilo & Stitch: The Series).