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Harbor Isle is a hamlet and census-designated place (CDP) in Nassau County, New York, United States. The population was 1,301 at the 2010 census. Harbor Isle is an unincorporated area of the Town of Hempstead and is not to be confused with Island Park.
Harbor Isle is located at 40°36′10″N 73°39′52″W. It is bordered by the Village of Island Park to the east, Hog Island Channel to the west and north, and Wreck Lead Channel to the south.
According to the United States Census Bureau, the CDP has a total area of 0.2 square miles (0.52 km2), of which, 0.2 square miles (0.52 km2) of it is land and 0.1 square miles (0.26 km2) of it (21.74%) is water.
As of the 2010 census, there were 1,301 people, 470 households, and 378 families residing in the CDP. The population density was 6,505 per square mile (2,512 per square kilometer). There were 495 housing units at an average density of 2,475 per square mile (956 per square kilometer). The racial makeup of the CDP was 94.8% White, 0.8% African American, 1.8% Asian, 1% from other races, and 1.7% from two or more races. Hispanic or Latino of any race were 5.9% of the population.