Hayti (pronounced "HAY-tie") is a city in eastern Pemiscot County, Missouri, United States. The population was 2,939 at the 2010 census.
Hayti was platted in 1894, when the railroad was extended to that point. According to one tradition, the name honors Dr. G. Hayes, an original owner of the site. It is also claimed the name is derived from the country of Haiti. A post office called Hayti has been in operation since 1895.
The city lies in eastern Pemiscot County, just west of the Mississippi River. Interstate 55 passes through the eastern half of Hayti, connecting the city with the Sikeston area to the north and Blytheville, Arkansas, to the south. Interstate 155 intersects I-55 near Hayti's southern border, and continues southeastward across the river into Tennessee. U.S. Route 412 connects Hayti to Kennett to the west, and Route 84 connects the city with Caruthersville to the east.