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Pascola is a village in Pemiscot County, Missouri, United States. The population was 108 at the 2010 census.
Pascola was platted in 1894 when the railroad was extended to that point. It is unclear why the name "Pascola" was applied to this community. The Pascola post office closed in 1992.
Pascola is located at 36°15′58″N 89°49′29″W (36.266017, -89.824785). The village lies northwest of Hayti at the intersection of State Route B and County State Route K. The former road connects Pascola to Homestown and Wardell to the north and U.S. Route 412 to the south, and the latter connects the village with Bragg City to the west.
According to the United States Census Bureau, the village has a total area of 0.16 square miles (0.41 km2), all land.
As of the census of 2010, there were 108 people, 48 households, and 26 families living in the village. The population density was 675.0 inhabitants per square mile (260.6/km2). There were 55 housing units at an average density of 343.8 per square mile (132.7/km2). The racial makeup of the village was 97.22% White, 0.93% from other races, and 1.85% from two or more races.