Millersburg is a home rule-class city in Bourbon County, Kentucky, United States. The population was 792 at the 2010 census. It is part of the Lexington–Fayette Metropolitan Statistical Area.
Millersburg was founded in 1817. It was named for John Miller. Probably from its founding and certainly from the appointment on 4 December 1833 of Charles Talbutt as postmaster, the post office was referred to as Millersburgh. (A K Vinney and A L Miller assumed the postmaster duties on 1 January 1836, then Oscar J Miller became postmaster on 15 May 1837). Some postmasters were appointed to "Millersburgh" and others to "Millersburg". The post office name officially changed from Millersburgh to Millersburg on 15 May 1889, exactly one month into the tenure of postmaster Ida B. Collier, and has since been known solely as Millersburg. John A Miller Sr.