Nettleton is a town in Lee and Monroe counties in Mississippi. The population was 1,992 at the 2010 census. Incorporated in 1888, the town was named after George Henry Nettleton, president of the Kansas City, Memphis and Birmingham Railroad (KCM&B).
Nettleton is located at 34°5′18″N 88°37′22″W (34.088218, -88.622701). The town sits on the boundary line between Lee County on the north and Monroe County on the south, with approximately equal portions of the town in either county. In the 2000 census, 1,196 of the town's 1,932 residents (61.9%) lived in Monroe County and 736 (38.1%) in Lee County.
According to the United States Census Bureau, the town has a total area of 2.7 square miles (7.0 km2), of which 2.7 square miles (7.0 km2) is land and 0.37% is water.
As of the census of 2000, there were 1,932 people, 794 households, and 546 families residing in the town. The population density was 714.8 people per square mile (276.3/km2). There were 868 housing units at an average density of 321.1 per square mile (124.1/km2). The racial makeup of the town was 66.56% White, 32.51% African American, 0.10% Native American, 0.36% Asian, 0.16% from other races, and 0.31% from two or more races.