Princess Anne is a town in Somerset County, Maryland, United States, that also serves as its county seat. Its population was 3,290 at the 2010 census. It is included in the Salisbury, Maryland–Delaware Metropolitan Statistical Area.
It is notable as the location of the University of Maryland Eastern Shore and the Teackle Mansion.
With a population just under 4,000, the town at the head of the Manokin River was named for Princess Anne of Great Britain, daughter of King George II. Established in 1733, it serves as the county seat for Somerset County, the southernmost county in Maryland.
In the mid-18th century, the town became a market center because of the river trade. This was later augmented by the southward extension of the Eastern Shore Railroad on Maryland's Eastern Shore. At that time, the Manokin River was navigable as far as the bridge at Princess Anne.
Much of the town's architectural heritage has been preserved. About 150 acres (0.6 km2) of the old town, with about 300 structures, is entered on the National Register of Historic Places as the Princess Anne Historic District.