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Rainelle is a small town on the western edge of Greenbrier County, West Virginia, in the United States. It sits at the base of Sewell Mountain and Sims Mountain, and is bisected by the Meadow River. The only means of transportation to and from Rainelle are roads; primarily US 60 and WV 20, which merge on the west end of the town, and the James River and Kanawha Turnpike, which enters from the south. The population was 1,505 at the 2010 census.
The valley and community that contain and predates Rainelle is named Sewell Valley after Stephen Sewell, a scout that settled in the area in the 1750s. The community west of the Meadow River first applied for the name Raine in honor of the Raine family but was turned down by the Post Office Department. They adopted the name Rainelle in 1909. Thomas W. Raine and his brother John moved to the location from Pennsylvania in 1906 to harvest a large stand of hardwoods for building homes, etc. Their Meadow River Lumber Company operated for 60 years, and at one time was the largest hardwood sawmill in the world. In 1970, the owners sold it to Georgia-Pacific Corporation, which tore it down in 1975.
The town has suffered from a few natural disasters in the last decade: most notably have been the June 2012 North American derecho, Hurricane Sandy, and the 2016 West Virginia flood.