Simpsonville is a city in Greenville County, South Carolina, United States. It is part of the Greenville–Mauldin–Easley Metropolitan Statistical Area. The population was 18,238 at the 2010 census, up from 14,352 in 2000. The population had risen to an estimated 24,221 as of 2019. Simpsonville is part of the "Golden Strip", along with Mauldin and Fountain Inn, an area which is noted for having low unemployment due to a diversity of industries including Para-Chem, Kemet, Sealed Air and Milliken.
The Burdette Building, Cureton-Huff House, Hopkins Farm, and Simpsonville Baptist Church are listed on the National Register of Historic Places.
In October 2018, a winning lottery ticket for a $1.6 billion Mega Millions jackpot was sold at the #7 KC Mart in Simpsonville.
Simpsonville is located in southeastern Greenville County at 34°44′0″N 82°15′36″W (34.733375, -82.260001), between Mauldin to the northwest and Fountain Inn to the southeast. The center of town has an elevation of 866 feet (264 m) above sea level.
South Carolina Highway 14 runs through the center of Simpsonville as Main Street, leading north 16 miles (26 km) to Greer and southeast 5 miles (8 km) to the center of Fountain Inn. The center of Mauldin is 4.5 miles (7.2 km) to the northwest via South Carolina Highway 417.