Tuttle is a city in Grady County, Oklahoma, United States. The population was 6,019 with the close of the 2010 census, seeing a 40.2% increase from 4,294 at the close of the 2000 census.
Located east of the Chisholm Trail, Tuttle was developed as a farming and ranching community. The town was platted in 1901 and the land was purchased Chickasaw land from the Colbert Family. The town is named after local rancher James H. Tuttle, a Choctaw by marriage and the father of automobile dealer and politico Holmes Tuttle.
At the time of its founding, Tuttle was located in Pickens County, Chickasaw Nation.
The right-of-way for the St. Louis and San Francisco Railway came from the tribal allotment of Frances Schrock, a Choctaw. Schrock Park is named after her. Tuttle's post office was established in 1902, and the town was incorporated in 1906.
Tuttle is located at 35°17′42″N 97°47′8″W (35.294963, -97.785683). According to the United States Census Bureau, the city has a total area of 29.2 square miles (76 km2), all land.