Walls is a town located in northern DeSoto County, Mississippi, United States, near the Mississippi River, part of the larger region known as "The Delta", and known for its rich, dark soil. As it is in the upper northwest corner of Mississippi, it is in the Memphis, Tennessee metropolitan area. Its ZIP code is 38680. As of the 2010 census it had a population of 1,162, with an estimated population of 1,463 in 2018.
A relatively young community, Walls was originally named "Alpika", an old Chickasaw Indian word. The name was changed to Walls in 1906.
Walls was named after Captain June Walls, who served in the Civil War. Captain Walls was an early settler and merchant of the region in the 1880s.
A Mississippian culture village site near Walls, the Walls Site, gives its name to the Walls Phase, the last prehistoric cultural expression before European contact. The historic trail of Hernando de Soto leads through DeSoto County to near Walls.
Today, Walls is a community rich in agriculture.