Williams is a town in Colleton County, South Carolina, United States. The population was 117 at the 2010 census.
The Tom Williams House was listed in the National Register of Historic Places in 1973.
Williams is located in northern Colleton County at 33°2′3″N 80°50′35″W (33.034076, -80.842928). It is 16 miles (26 km) northwest of Walterboro, the county seat.
According to the United States Census Bureau, the town has a total area of 0.85 square miles (2.2 km2), all land.
As of the census of 2000, there were 116 people, 48 households, and 33 families residing in the town. The population density was 147.5 people per square mile (56.7/km²). There were 59 housing units at an average density of 75.0 per square mile (28.8/km²). The racial makeup of the town was 53.45% White, 44.83% African American, 0.86% from other races, and 0.86% from two or more races. Hispanic or Latino of any race were 0.86% of the population.
There were 48 households out of which 20.8% had children under the age of 18 living with them, 60.4% were married couples living together, 10.4% had a female householder with no husband present, and 29.2% were non-families. 25.0% of all households were made up of individuals and 18.8% had someone living alone who was 65 years of age or older.