Walterboro is a city in Colleton County, South Carolina, United States. The city's population was 5,398 at the 2010 census. It is the county seat of Colleton County. Walterboro is located 48 miles (77 km) west of Charleston and is located near the ACE Basin region in the South Carolina Lowcountry. It is known as "The Front Porch of the Lowcountry".
Walterboro (original spelling: "Walterborough") was founded in 1783, as a summer retreat for local planters looking to escape their malaria-ridden, Lowcountry plantations. The original settlement was located on a hilly area, covered with pine and hickory trees and named "Hickory Valley". Two of the earliest settlers were brothers, Paul and Jacob Walter. The brothers were prosperous, plantation owners, in nearby Jacksonboro. Paul's small daughter Mary, was taken ill with malaria; a common disease amongst the families who constructed and cultivated their plantations in the marshy areas of the Lowcountry, due to the grounds suitability for rice production.